How will genetic patents affect scientific research?

There is a stereotype of scientists as individuals motivated purely by the search for objective truth. In pursuit of these truths they engage in think tanks and peer review, freely publishing their findings to ensure a high standard of objectivity in their own work. This free flow of information is seen as a benefit to the field as a whole by enabling others in the field to build on previous work.

Whether patents will limit the cooperation among researchers apparently depends on the risks perceived by the patent owners. A patent on a DNA sequence provides the owner with exclusionary rights over the “tangible DNA molecules and constructs, but does not prevent anyone from perceiving, using and analyzing information about what the DNA sequence is.”[1] In theory, the owner of a gene that has the potential to be useful in the diagnosis or treatment of a disease should be willing to freely share access to the gene. In doing so, the patent holder is in a position to profit from this sharing. This could be strong motivation for researchers to patent as many genes as possible and to make access to these genes as easy as possible. In such a system, we would expect genetic research to be both highly competitive and open to the sharing of ideas and information. There is some evidence that “…patent holders tend not to enforce their rights against basic scientific uses…”[2] but with more and more educational institutions applying for patents, research by other organizations, even pure research, might be seen as competition.

By contrast, individuals concerned with DNA sequencing will often face risks greater than the benefits provided by the exclusionary rights provided by a patent. As genetic sequences are uncovered, they can often be used as starting points for future discoveries. Having a patent on a sequence alone opens the door for other researchers to “scoop” new patents on the proteins a sequence might code for, or potential uses of the sequence. In this arena, researchers would benefit from playing their cards close to their chests in order to prevent such an infringement. At least early in the process of genetic sequencing, then, we can see how channels of communication between researchers might shut down.

“University scientists who might otherwise be colleagues in the scientific enterprise became business competitors jockeying for commercial advantage. Moreover, there soon was a greater willingness to suppress or distort research, several peer-reviewed studies have shown. Scientists became less willing to share critical research tools and bio-materials. Old habits of openness and collegiality gave way to non-disclosure agreements and material transfer licenses.” [3]

[1] From Eisenberg, Rebecca S. “How Can You Patent Genes?” in Who Owns Life.
[2] From Wilson, Jack. “Patenting Organisms: Intellectual Property Law Meets Biology.” in Who Owns Life.
[3] “Falling From Grace: Science and the Pursuit of Profit” by Robert Lee Hotz

The Center for Bioethics at the University of Pennsylvania
 Sponsored by: Geraldine R. Dodge Foundation & Kenneth Scott Charitable Trust